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. 2017 Oct 12;8:797. doi: 10.3389/fphys.2017.00797

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Copyright © 2017 Smit, Cócera Ortega, Végh, Meijborg, Smits, Klerk, Tijsen, Tan, Goumans, Boink and Coronel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CMPCs or Cme on conduction velocity. (A) An example of the local electrograms recorded and the corresponding activation map for each of the different cultures investigated. (B) A scatter-plot showing the effects of CMPCs and Cme CMPC on conduction velocity. Conduction velocity is calculated along lines perpendicular to the isochronal lines. Black boxes indicate electrodes excluded from analysis and black dashed lines represent isochrones lines. Cme, conditioned medium; CMPCs, cardiomyocyte progenitor cells; and NRVMs, neonatal rat ventricular myocytes. The ^*indicates a p < 0.001 compared to both control monolayers and monolayers cultured in Cme CMPC.