Figure 6.

Petrosiol E protects cells against oxidative stress and promotes neurite outgrowth under arsenic exposure. PC12 cells were pretreated with Petrosiol E at 0.6, 1.25, and 2.5 µg mL⁻¹ for 1 h, and were further treated with arsenic at 1.3 mg mL⁻¹ for dictated time. Thereafter, A) SOD and B) catalase activities, and C) SOD and catalase concentrations were determined on day 1. Furthermore, D) cellular morphology, E) quantitative analysis of neurite bearing cells (n = 6), and F) NEFL levels were assessed on day 3. All the experiments were repeated for three times. #: P < 0.001, relative to control.