Table 4.
Effect of cell dose used for BMC transplantation left ventricular function
| No. of RCTs | Difference in mean (95% CI) | P value | |
|---|---|---|---|
| LV ejection fraction | |||
| Cell dose ≤ 10^7 | 3 | 1.91 [–0.05 to 3.87] | 0.06 |
| Cell dose > 10^7, ≤ 10^8 | 11 | 1.56 [–2.95 to 6.06] | 0.50 |
| Cell dose > 10^8, ≤ 10^9 | 16 | 1.65 [0.22 to 3.09] | 0.02 |
| Cell dose > 10^9, ≤ 10^10 | 4 | 5.87 [0.79 to 10.95] | 0.02 |
| LV end-diastolic indexes | |||
| Cell dose ≤ 10^7 | 3 | –6.00 [–15.20 to 3.20] | 0.20 |
| Cell dose > 10^7, ≤ 10^8 | 8 | –7.36 [–11.45 to –3.27] | 0.0004 |
| Cell dose > 10^8, ≤ 10^9 | 12 | –0.69 [–2.22 to 0.83] | 0.37 |
| Cell dose > 10^9, ≤ 10^10 | 3 | 4.63 [–1.74 to 11.00] | 0.15 |
| LV end-systolic indexes | |||
| Cell dose ≤ 10^7 | 3 | –8.01 [–17.88 to 1.87] | 0.11 |
| Cell dose > 10^7, ≤ 10^8 | 6 | –12.99 [–19.07 to –6.91] | < 0.0001 |
| Cell dose > 10^8, ≤ 10^9 | 11 | 0.32 [–1.62 to 2.26] | 0.75 |
| Cell dose > 10^9, ≤ 10^10 | 3 | –1.50 [–6.90 to 3.89] | 0.59 |
RCTs randomized controlled trials, 95% CI 95% confidence interval