Table 3.
Pharmacodynamic effects compared with placebo
| Test parameter | Cohort 1: Gln-1062 5.5 mg | Cohort 2: Gln-1062 11 mg | Cohort 3: Gln-1062 22 mg | Cohort 4: Gln-1062 33 mg | Cohort 5: Gln-1062 44 mg |
|---|---|---|---|---|---|
| Adaptive tracking (%) | 1.96 (−0.88 to 4.80) P = .1581 | 3.47 (0.52 to 6.42) P = .0247 | 0.64 (−1.06 to 2.35) P = .4474 | 1.79 (0.07 to 3.52) P = .0424 | 0.74 (−0.99 to 2.48) P = .3887 |
| VVLT: immediate word recall trial 1 | 3.42 (−0.73 to 7.56) P = .0984 | 3.92 (−0.23 to 8.06) P = .0621 | 2.67 (0.17 to 5.16) P = .0367 | 1.97 (−0.65 to 4.58) P = .1355 | 2.57 (−0.05 to 5.18) P = .0541 |
| VVLT: immediate word recall trial 2 | 3.17 (−1.93 to 8.26) P = .2025 | 1.83 (−3.26 to 6.93) P = .4510 | 3.50 (0.33 to 6.67) P = .0315 | 1.77 (−1.56 to 5.09) P = .2880 | 1.77 (−1.56 to 5.09) P = .2880 |
| VVLT: immediate word recall trial 3 | 5.00 (−0.58 to 10.58) P = .0749 | 3.00 (−2.58 to 8.58) P = .2662 | 0.67 (−3.23 to 4.56) P = .7302 | 0.60 (−3.49 to 4.69) P = .7672 | 1.00 (−3.09 to 5.09) P = .6222 |
| VVLT: delayed word recall | 3.42 (−2.62 to 9.45) P = .2431 | 3.25 (−2.79 to 9.29) P = .2657 | −0.33 (−3.58 to 2.91) P = .8354 | −0.00 (−3.63 to 3.63) P = 1.0000 | −1.00 (−4.63 to 2.63) P = .5780 |
| VVLT: word recognition | −0.15 (−8.05 to 7.75) P = .9674 | 1.45 (−6.45 to 9.35) P = .6939 | 0.87 (−4.09 to 5.82) P = .7231 | −0.67 (−6.45 to 5.12) P = .8153 | 2.17 (−3.11 to 7.45) P = .4083 |
| N-back, 0-back (correct-incorrect/total) | 0.04 (−0.02 to 0.10) P = .1696 | 0.03 (−0.03 to 0.09) P = .3145 | 0.02 (−0.02 to 0.05) P = .3729 | 0.03 (−0.01 to 0.06) P = .1690 | 0.03 (−0.00 to 0.07) P = .0654 |
| N-back, 1-back (correct-incorrect/total) | −0.00 (−0.17 to 0.16) P = .9835 | −0.05 (−0.21 to 0.12) P = .5597 | 0.02 (−0.02 to 0.06) P = .3402 | −0.03 (−0.07 to 0.02) P = .2212 | −0.01 (−0.06 to 0.03) P = .5016 |
| N-back, 2-back (correct-incorrect/total) | 0.09 (−0.06 to 0.25) P = .2199 | 0.13 (−0.02 to 0.28) P = .0867 | −0.02 (−0.09 to 0.06) P = .6835 | −0.02 (−0.10 to 0.06) P = .5957 | 0.02 (−0.05 to 0.10) P = .5430 |
| Face recognition number correct | −0.77 (−4.17 to 2.64) P = .6332 | 4.54 (1.22 to 7.87) P = .0116 | −2.58 (−7.22 to 2.06) P = .2642 | −0.54 (.5.15 to 4.08) P = .8135 | −1.63 (−6.30 to 3.05) P = .4822 |
| Stroop (correct congruent – correct incongruent) | −0.39 (−0.94 to 0.15) P = .1411 | −0.60 (−1.21 to 0.01) P = .0535 | 0.10 (−1.05 to 1.25) P = .8606 | 0.58 (−0.52 to 1.68) P = .2909 | 0.11 (−0.98 to 1.20) P = .8406 |
| EEG alpha Fz-Cz (uV) | −13.2% (−30.5% to 8.5%) P = .1914 | −0.8% (−19.5% to 22.1%) P = .9310 | 7.8% (−7.0% to 25.1%) P = .3088 | 21.5% (4.8% to 40.8%) P = .0116 | −10.1% (−24.2% to 6.6%) P = .2121 |
| EEG alpha Pz-Oz (uV) | −8.9% (−23.8% to 8.9%) P = .2782 | −13.1% (−27.2% to 3.7%) P = .1086 | 13.8% (−5.4% to 36.9%) P = .1633 | 19.7% (−0.2% to 43.6%) P = .0530 | 2.1% (−16.3% to 24.5%) P = .8306 |
| Saccadic peak velocity (°/s) | 9.90 (−17.50 to 37.30) P = .4465 | 8.32 (−18.32 to 34.95) P = .5097 | 26.92 (4.11 to 49.73) P = .0223 | 0.92 (−21.84 to 23.68) P = .9349 | 19.19 (−5.54 to 43.92) P = .1242 |
| Saccadic inaccuracy (%) | −1.56 (−2.77 to −0.35) P = .0157 | −1.78 (−3.03 to −0.54) P = .0088 | 0.24 (−1.01 to 1.48) P = .7005 | 0.08 (−1.14 to 1.30) P = .8970 | −0.22 (−1.57 to 1.12) P = .7363 |
Abbreviations: VVLT, visual verbal learning test; EEG, electroencephalogram.
NOTE. Mean, confidence interval in parentheses.