Figure 3.

Propofol blocked NMDA receptor-mediated calcium influx in vitro. In each group, fluorescence responses were normalized to maximal calcium fluorescence induced by Ionomycin. The effects of pre-emptive 3 µM (a) and 10 µM (b) propofol were illustrated. *P < 0.05, **P < 0.01 versus NG group, n = 13, one-way ANOVA followed by Dunnett’s multiple comparisons test. P3: 3 µM of propofol; NG: NMDA and glycine; P3 + NG: pre-treatment with 3 µM of propofol for 1 h followed by NMDA and glycine; P10: 10 µM of propofol; P10 + NG: pre-treatment with 10 µM of propofol for 1 h followed by NMDA and glycine.