Mice repeatedly treated with THC or CP47,497 displayed tolerance to the cannabimimetic effects of CP47,497.
(A) THC- and CP47,497-treated mice exhibited marked tolerance to the cataleptic effects of CP47,497. (B) The antinociceptive effects of CP47,497 underwent tolerance following repeated drug administration and cross-tolerance to repeated THC administration. (C) The hypothermic effects of CP47,497 underwent tolerance following repeated drug administration and cross-tolerance to repeated THC administration. Values represent means±SEM. Filled symbols indicate p < 0.05 vs. vehicle, **p < 0.01 vs. THC.