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. Author manuscript; available in PMC: 2017 Oct 17.
Published in final edited form as: J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):217–228. doi: 10.1515/jbcpp-2015-0118

Figure 7.

Figure 7

Mice repeatedly treated with THC or CP47,497 displayed tolerance to the cannabimimetic effects of CP47,497.

(A) THC- and CP47,497-treated mice exhibited marked tolerance to the cataleptic effects of CP47,497. (B) The antinociceptive effects of CP47,497 underwent tolerance following repeated drug administration and cross-tolerance to repeated THC administration. (C) The hypothermic effects of CP47,497 underwent tolerance following repeated drug administration and cross-tolerance to repeated THC administration. Values represent means±SEM. Filled symbols indicate p < 0.05 vs. vehicle, **p < 0.01 vs. THC.