Table 3.
Predictive factors for overall survival by univariate and multivariate analyses of the cohort (n=100).
| Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Gender | ||||||
| Female | 1 | – | ||||
| Male | 1.13 | 0.55–2.33 | 0.74 | – | – | – |
| T stage | ||||||
| T3 | 1 | – | ||||
| T4 | 1.13 | 0.55–2.33 | 0.74 | – | – | – |
| N stage | ||||||
| N(−) | 1 | – | ||||
| N(+) | 0.85 | 0.36–1.99 | 0.70 | – | – | – |
| Stage | ||||||
| II | 1 | – | ||||
| III | 0.96 | 0.39–2.35 | 0.92 | – | – | – |
| Preoperative HB level | ||||||
| <10 | 1 | – | ||||
| ≥10 | 1.47 | 0.35–6.21 | 0.60 | – | – | – |
| Tumor size, cm | ||||||
| <5 | 1 | – | ||||
| ≥5 | 1.75 | 0.61–5.03 | 0.30 | – | – | – |
| Interval from CCRT to operation, wk | ||||||
| <7 | 1 | 1 | ||||
| ≥7 | 0.37 | 0.15–0.91 | 0.03 | 0.49 | 0.20–1.23 | 0.13 |
| Total dose of RT, Gy | ||||||
| <50 | 1 | – | ||||
| ≥50 | 0.90 | 0.41–1.95 | 0.79 | – | – | – |
| Preoperative AFP levels, U/ml | ||||||
| <10 | 1 | – | ||||
| ≥10 | 0.91 | 0.12–6.72 | 0.93 | – | – | – |
| Preoperative CEA levels, U/ml | ||||||
| <5 | 1 | – | ||||
| ≥5 | 1.69 | 0.81–3.55 | 0.17 | – | – | – |
| Lymphovascular invasion | ||||||
| Negative | 1 | 1 | ||||
| Positive | 3.23 | 1.35–7.75 | 0.009 | 2.29 | 0.92–5.74 | 0.076 |
| Perineural invasion | ||||||
| Negative | 1 | – | ||||
| Positive | 1.68 | 0.68–4.12 | 0.26 | – | – | – |
| NLR | ||||||
| Low (<2.25) | 1 | 1 | ||||
| High (≥2.25) | 3.87 | 1.35–11.11 | 0.012 | 2.87 | 0.87–9.43 | 0.082 |
| PLR | ||||||
| Low (<150) | 1 | 1 | ||||
| High (≥150) | 2.00 | 0.93–4.30 | 0.074 | 0.70 | 0.27–1.80 | 0.46 |
| LMR | ||||||
| Low (<3) | 1 | 1 | ||||
| High (≥3) | 0.31 | 0.14–0.64 | 0.002 | 0.43 | 0.18–1.00 | 0.045 |