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. 2017 Jul 25;4(5):e1356431. doi: 10.1080/23723556.2017.1356431

Figure 1.

Figure 1.

Autophagosome formation at ER-plasma membrane contact sites. Proposed scheme of action for E-Syts (extended synaptotagmins, regulators of Endoplasmic Reticulum (ER) – plasma membrane contact sites) and VMP1 (vacuolar membrane protein 1) in the recruitment of the autophagy machinery at ER-plasma membrane contact sites. The tethering protein E‐Syt2 forms a complex with VMP1 and Beclin1, two regulators of PI3KCIII (class III PI3kinase) complex activity, to initiate local PI3P (phosphatidylinositol-3-phosphate) synthesis and autophagosome biogenesis.