Figure 3.

Effect of inflammasome inhibitors.

Notes: Secretion of IL-1β after incubation of BMDMs (A) and BMDCs (B) with a caspase-1 inhibitor. Secretion of IL-1β after incubation of BMDMs (C) and BMDCs (D) with a cathepsin B inhibitor. All data were obtained in triplicate and are presented as the mean ± SD. ^***p<0.001. The concentration unit of the X-axis is µg mL⁻¹, and poly-(dA:dT) is 2 µg mL⁻¹ (1: control, 2: 5 µg mL⁻¹, 3: 10 µg mL⁻¹, 4: poly-(dA:dT)).

Abbreviations: BMDCs, bone marrow-derived dendritic cells; BMDMs, bone marrow-derived macrophages; poly-(dA:dT), poly(deoxyadenylic–deoxythymidylic).