Table 5.

Statistics on the 21 annotated entities

Class	Entity	No mentions	No unique mentions	No labels included
Nanomedicine description	Company	197	69	41
	FDA approval date	34	19	41
	Trade name	6,716	41	41
	US patent	31	31	8
Physicochemical characterization	Active ingredient	2,161	61	41
	Core composition	89	26	16
	Molecular weight	50	40	34
	Nanoparticle	854	42	41
	Particle diameter	7	6	6
	Surface coating	62	11	15
Pharmacokinetic parameters	AUC	47	46	19
	Clearance	49	46	24
	Cmax	45	42	20
	Elimination half-life	16	15	11
	Plasma half-life	56	53	13
	Tmax	30	18	14
	Volume of distribution	29	27	19
Exposure	Dose	2,283	542	41
	Route of administration	1,192	20	41
Biologic response	Adverse reaction	6,689	1,773	41
	Indication	1,396	162	41

Abbreviations: AUC, area under the curve; Cmax, maximum concentration measured in blood; FDA, US food and drug administration; Tmax, time to reach Cmax.