Table 3.
Binding of human and animal factor H to CRASPs of B. burgdorferi s.s.
| Serum Source a | CspABb (BBA68) | CspABa | CspZ (BBH06) | ErpP (BBN38) | ErpC | ErpA (BBL39) |
|---|---|---|---|---|---|---|
| Human | + | + | + | + | + | + |
| Mouse | (+) | (+) | + | (+) | (+) | (+) |
| Rat | − | − | − | − | + | − |
| Rabbit | − | ND | +/− | − | ND | − |
| Cat | − | − | − | − | ND | − |
| Dog | − | − | − | + | ND | − |
| Sheep | − | ND | ND | − | ND | − |
| Horse | − | − | − | − | ND | − |
| Cow | − | − | + | + | ND | − |
| Pig | − | ND | + | + | ND | − |
Symbols in parenthesis indicate controversial results of Factor H binding to the respective CRASP protein. Further studies are required to unambiguously determine whether the respective proteins interact with factor H; a binding of human and animal factor H to purified proteins was assessed by different Western blotting approaches [70,72,75,77,78,88,89,95]; ND, no data available; Bb, B. burgdorferi s.s.; Ba, B. afzelii; Csp, complement regulator-acquiring surface protein; Erp, OspE/F-related protein; synonyms of protein names are indicated in brackets.