Table 2.
Overview of distribution of the ABC transporters P-gp, MRP1, MRP2 and BCRP in selected human barrier tissues [55,63].
| Tissue | P-gp | MRP1 | MRP2 | BCRP |
|---|---|---|---|---|
| Lung | apical | basolateral | not detected | apical |
| Intestine | ||||
| Duodenum | apical | basolateral | apical | apical |
| Jejunum | apical | basolateral | apical | apical |
| Ileum | apical | basolateral | apical | apical |
| Colon | apical | basolateral | apical | apical |
| Liver | apical | basolateral | not detected | apical |
| Kidney | apical | basolateral | apical | not detected |
| Brain | ||||
| BBB | apical | apical | apical | apical |
| BCSFB | apical | basolateral | - | - |
| Testis | apical | basolateral | not detected | not detected |
| Placenta | apical | basolateral | apical | apical |
BBB = blood-brain barrier, BCSFB = blood-cerebrospinal fluid barrier.