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. 2015 Aug 12;2(3):150–184. doi: 10.3390/vetsci2030150

Table 4.

A selection of clinically relevant drugs and compounds that are known P-gp substrates [55,68].

Drugs Used in Oncology Non-Oncological Drugs
Cytotoxic agents Anthracyclines doxorubicin, daunorubicin, epirubicin Antibiotics doxycycline, erythromycin, rifampin, tetracycline
Anthracenes mitoxantrone, bisantrene Antifungals itraconazole, ketoconazole
Antitumor antibiotics actinomycin-D, mitomycin-C, plicamycin mithramycin) Antiparasiticides ivermectin, moxidectin, selamectin
Taxanes paclitaxel, docetaxel Antiemetics domperideone, ondansetron
Topoisomerase I inhibitors (campothecins) irinotecan, topotecan Antidiarrheal agents loperamide
Topoisomerase II inhibitors (epipodophyllotoxins) etoposide, teniposide Anticonvulsant drugs phenobarbital, phenytoin, levetiracetam
Vinca-alkaloids vincristine, vinblastine, vinorelbine, vindesine Cardiac drugs digoxin, diltiazem, quinidine, verapamil losartan
Antihistamines (H2-antagonsits) cimetidine, ranitidine, terfenadine
Steroids Glucocorticoids cortisol, dexamethasone, hydrocortisone, methylprednisolone, prednisolone, triamcinolone Immunosupppressants cyclosporine A, tacrolimus
Mineralocorticoids aldosterone Opioids butorphanol, morphine
Sex steroids estradiol, progesterone Miscellaneous amitryptiline, colchicine, phenothiazines
Tyrosine kinase inhibitors imatinib, gefitinib