MMVD	Myxomatous mitral valve disease
RT-PCR	Real time polymerase chain reaction
VEC	Valvular endothelial cell
LAMA	Laminin
NID	Nidogen
GAG	Glycosaminoglycan
VIC	Valvular interstitial cell
ECM	Extracellular matrix
FED	Fibroelastic deficiency
MVP	Mitral valve prolapse
FDR	False discovery rate
COL	Collagen
LUM	Lumican
VCAN	Versican
MMP	Matrix-metalloproteinase
TIMP	Tissue inhibitor of metalloproteinase
KEGG	Kyoto Encyclopedia of Genes and Genomes
EndoMT	Endothelial-to-mesenchymal transition
α-SMA	Alpha-smooth muscle actin
CD31	Platelet endothelial cell adhesion molecule 1
CDH5	Vascular endothelial cadherin
HAS2	Hyaluronic synthase 2
IHC	Immunohistochemistry
TGF-β	Transforming growth factor–β
SMAD	Suppressor of mothers against decapentaplegic
BMP	Bone morphogenetic proteins
COMP	Cartilage oligomeric matrix protein
ENG	Endoglin
TGFBI	TGF-β-induced
CTGF	Connective tissue growth factor
5-HT	5-hydroxytryptamine
TPH1	Tryptophan hydroxylase 1
AGT2	Angiotensin 2
AT1	AGT2 type 1 receptor
ADAMTS	A Disintegrin And Metalloproteinase with Thrombospondin Motifs
SLRP	Small leucine-rich proteoglycans
CHAD	Chondroadherin
KERA	Keratocan
HAPLN1	Hyaluronan and proteoglycan link protein 1
TNF-α	Tumor necrosis factor α
NFκB	Nuclear factor kappa-light-chain-enhancer of activated B cells
LDLR	Lipoprotein receptor
HSP	Heat shock proteins
ROS	Reactive oxygen species
NOX	Nicotinamide adenine dinucleotide phosphate-oxidase
SOD	Superoxide dismutase
ncRNAs	Non-coding RNAs
miRs	MicroRNAs