Table 1.
Characterized inhalant mammalian allergens (listed in the WHO/IUIS allergen database www.allergen.org).
| Animal | Major Allergens | Protein Family | Main Source | MW § (kDa) | Sensitization Rate # [Reference] | Other Allergens |
|---|---|---|---|---|---|---|
| Cat | Fel d 1 * | Secretoglobin | Saliva, dander | 18 | 84–100% [26,27,28,29,30] | Fel d 2 * (albumin) |
| Fel d 4 * | Lipocalin | Saliva | 22 | 31–63% [27,28,29,30,31] | Fel d 3 (cystatin) | |
| Fel d 5 (IgA) | ||||||
| Fel d 6 (IgM) | ||||||
| Fel d 7 (lipocalin) | ||||||
| Fel d 8 (latherin) | ||||||
| Dog | Can f 1 * | Lipocalin | Saliva, dander | 23–25 | 40–76% [27,28,29,30,32] | Can f 2 * (lipocalin) |
| Can f 5 * | Kallikrein | Urine | 28 | 31–71% [27,28,29,33] | Can f 3 * (albumin) | |
| Can f 4 (lipocalin) | ||||||
| Can f 6 (lipocalin) | ||||||
| Can f 7 (NPC2 protein) | ||||||
| Horse | Equ c 1 * | Lipocalin | Dander, saliva | 25 | 51–76% [27,30,34] | Equ c 2 (lipocalin) |
| Equ c 4 | Latherin | Dander, saliva | 17, 20.5 | 77% [35] | Equ c 3 * (albumin) | |
| Cow | Bos d 2 | Lipocalin | Dander | 20 | 83–97% [34,36] | Bos d 3 (calcium-binding protein) |
| Bos d 6 * (albumin) | ||||||
| Mouse | Mus m 1 * | Lipocalin | Urine | 17 | 66% [34] | |
| Rat | Rat n 1 | Lipocalin | Urine | 17 | 88% [37] | |
| Guinea pig | Cav p 1 | Lipocalin | Dander, saliva | 20 | 70–87% [38] | Cav p 3 (lipocalin) |
| Cav p 2 | Lipocalin | Saliva, dander | 17 | 65% [39] | Cav p 4 (albumin) | |
| Cav p 6 (lipocalin) | ||||||
| Golden hamster | Mes a 1 | Lipocalin | Saliva, urine, fur | 20.5; 24; 30 | 67–83% [40] | |
| Siberian hamster | Phod s 1 | Lipocalin | Saliva, urine, fur | 18, 21, 23 | 100% [41] | |
| Rabbit | Ory c 1 | Lipocalin | Fur, saliva | 17–18 | 100% [42] | Ory c 4 (lipocalin) |
| Ory c 3 | Secretoglobin | Fur | 19–21 | 77% [43] |
* Allergens available for component-resolved allergen diagnostics (ImmunoCAP System or Immuno Solid-Phase Allergen Chip (ISAC), Thermo Fisher Scientific, Phadia AB, Uppsala, Sweden). § Apparent molecular weight (MW) in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). # Sensitization rates are based on different studies with different patient groups and test systems (immunoblot, crossed immunoelectrophoresis, ELISA, ImmunoCAP).