Skip to main content
. 2017 Jun 29;33(11):1905–1916. doi: 10.1007/s00381-017-3458-2

Table 3.

Genotype distribution of the five polymorphisms in infants without and with IVH or without/with IVH grades 1–2 and with IVH grades 3–4

Gene symbol Group without IVH
N = 55 (%)		 Group with IVH grades 1–4
N = 45 (%)		 p value OR Group without IVH and IVH grade 1 and 2
N = 89 (%)		 Group with IVH grades 3–4
N = 11 (%)		 p value OR
IL-1β
+3953 C>T(rs1143634)
 Genotype
   CC obs
  exp		 32 (58.18)
31.31		 30 (66.67)
28.8		 – References 53 (59.55)
51.19		 9 (81.82)
9.06		 – References
   CT obs
  exp		 19 (34.55) 20.37 12 (26.67)
14.4		 0.509 0.674 (0.253–1.761) 29 (32.58)
32.61		 2 (18.18)
1.82		 0.436 0.406 (0.040–2.173)
   TT obs
  exp		 4 (7.27)
3.31		 3 (6.66)
1.8		 1.000 0.800 (0.108–5.178) 7 (7.87)
5.19		 0 (0.00)
0.09		 0.716 0.000 (0.000–4.916)
  H-W 0.883 0.535 H-W 0.579 0.946
 Allele
   C 83 (75.45) 72 (80) – References 135 (75.84) 20 (90.9) – References
   T 27 (24.55) 18 (20) 0.553 0.769 (0.367–1.586) 43 (24.15) 2 (9.1) 0.596 0.628 (0.148–2.024)
 Genotype
   1/1 obs
  exp		 28 (50.91)
25.83		 22 (48.89)
19.78		 – References 46 (51.69)
41.86		 4 (36.36)
3.84		 – References
IL-1RN 86 bp VNTR (rs2234663)
   1/2 obs
  exp		 18 (32.73)
22.34		 15 (33.33)
19.44		 1.000 1.061 (0.398–2.807) 28 (31.46)
36.28		 5 (45.45)
5.32		 0.501 2.054 (0.401–11.17)
   1/3 1 (1.82) 1 (2.22) 1.000 1.273 (0.016–103.4) 2 (2.25) 0 (0.00) 1.000 0.000 (0.000–71.11)
   2/2 obs
  exp		 7 (12.73)
4.83		 7 (15.51)
4.78		 0.920 1.273 (0.325–4.957) 12 (13.48)
7.86		 2 (18.18)
1.84		 0.785 1.917 (0.154–15.15)
   2/3 1 (1.82) 0 (0.00) 1.000 0.00 (0.00–51.41) 1 (1.12) 0 (0.00) 1.000 0.000 (0.000–458.3)
  H-W 0.368 0.317 H-W 0.106 0.981
 Allele
   1 75 (68.18) 60 (66.66) – References 122 (68.53) 13 (59.1) – References
   2 33 (30) 29 (32.22) 0.879 1.098 (0.573–2.097) 53 (29.77) 9 (40.9) 0.437 1.594
(0.563–4.308)
   3 2 (1.81) 1 (1.11) 1.000 0.625 (0.010–12.31) 3 (1.68) 0 1.000 0.00
(0.000–24.38)
IL-6
-174 G>C(rs1800795)
 Genotype
   GG obs
  exp		 13 (23.64)
16.32		 8 (17.78)
8.60		 – References 19 (21.35)
22.75		 2 (18.18)
3.84		 – References
   GC obs
  exp		 33 (60.00)
28.36		 28 (62.22)
20.81		 0.718 1.379 (0.450–4.416) 52 (58.43)
44.49 		9 (81.82)
5.32		 0.850 1.644 (0.298–16.9)
   CC obs
  exp		 9 (16.36)
12.32		 9 (20.00)
12.60		 0.672 1.625 (0.379–7.013) 18 (20.22)
21.75 		0 (0.00)
1.84 		0.567 0.000 (0.000–6.185)
  H-W 0.209 0.081 H–W 0.282 0.072
 Allele
   G 59 (53.63) 44 (48.88) – References 90 (50.56) 13 (59.1) – References
   C 51 (46.36) 46 (51.11) 0.599 1.209 (0.667–2.195) 88 (49.43) 9 (40.9) 0.599 0.708 (0.254–1.899)
IL-6
−596 G>A(rs1800797)
 Genotype
   GG obs
  exp		 15 (27.28)
16.91		 8 (17.78)
11.25		 – References 21 (23.60)
24.29 		2 (18.18)
3.84 		– References
   GA obs
  exp		 31 (56.36)
27.17		 29 (64.44)
22.50		 0.388 1.754 (0.587–5.504) 51 (57.30)
44.41 		9 (81.82)
5.32 		0.721 1.853 (0.338–18.93)
   AA obs
  exp		 9 (16.36)
10.91		 8 (17.78)
11.25		 0.647 1.667 (0.384–7.223) 17 (19.10) 20.29 0 (0.00)
1.84 		0.649 0.000 (0.000–7.201)
  H-W 0.579 0.153 H–W 0.375 0.072
 Allele
   G 61 (55.45) 45 (50) – References 93 (52.24) 13 (59.1) – References
   A 49 (44.55) 45 (50) 0.531 1.245
(0.686–2.261) 		85 (47.75) 9 (40.9) 0.707 0.758 (0.271–2.031)
TNF-α−308G>A (rs1800629)
 Genotype
   GG obs
  exp		 42 (76.36)
42.77		 35 (77.78)
35.56		 – References 69 (77.53)
70.12 		8 (72.73)
8.20 		– References
   GA obs
  exp		 13 (23.64)
11.46		 10 (22.22)
8.89		 1.000 0.923 (0.320–2.603) 20 (22.47)
17.75 		3 (27.27)
2.59 		0.973 1.294 (0.202–60.51)
   AA obs
  exp		 0 (0.00)
0.77		 0 (0.00)
0.56		 – – 0 (0.00)
1.12 		0 (0.00)
0.20 		– –
  H-W 0.610 0.704 0.490 0.872
 Allele
   G 97 (88.18) 80 (88.88) – References 158 (88.76) 19 (86.36) – References
   A 13 (11.82) 10 (11.11) 1.000 0.933 (0.346–2.443) 20 (11.23) 3 (13.63) 0.957 1.247 (0.217–4.823)

Obs observed, Exp expected (genotype frequencies calculated from allele frequencies with the Hardy–Weinberg (H-W) equation)