Table 4.
Genotype distribution of polymorphisms in infants born 24 + 0–28 + 6 weeks of gestation without and with IVH or without/with IVH grades 1–2 and with IVH grades 3–4
| Gene symbol | Group without IVH N = 19 (%) |
Exp | Group with IVH grades 1–4 N = 35 (%) |
Exp | p value | OR | Group without IVH and IVH grade 1 and 2 N = 44 (%) |
Exp | Group with IVH grades 3–4 N = 10 (%) |
Exp | p value | OR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IL-1β +3953 C>T(rs1143634) | ||||||||||||
| Genotypes | ||||||||||||
| CC | 10 (52.63) | 10.32 | 25 (71.43) | 24.03 | – | References | 27 (61.36) | 26.27 | 8 (80.00) | 8.10 | – | References |
| CT | 8 (42.11) | 7.37 | 8 (22.86) | 9.94 | 0.243 | 0.4 (0.099–1.625) |
14 (31.82) | 15.45 | 2 (20.00) | 1.80 | 0.648 | 0.482 (0.045–2.939) |
| TT | 1 (5.26) | 1.32 | 2 (5.71) | 1.03 | 1.000 | 0.8 (0.038–51.86) |
3 (6.82) | 2.27 | 0 (0.00) | 0.10 | 0.963 | 0 (0.000–9.542) |
| H-W | 0.933 | 0.513 | 0.823 | 0.940 | ||||||||
| Allele | ||||||||||||
| C | 28 (73.68%) | 58 (82.85%) | – | References | 68 (77.27%) | 18 (90%) | – | References | ||||
| T | 10 (26.31%) | 12 (17.15%) | 0.377 | 0.579 (0.202–1.703) |
20 (22.72%) | 2 (10%) | 0.442 | 0.425 (0.044–2.078) |
||||
| IL-1RN86 bp VNTR (rs2234663) | ||||||||||||
| Genotypes | ||||||||||||
| 1/1 | 9 (47.37) | 6.72 | 18 (51.43) | 16.46 | – | References | 24 (54.55) | 20.24 | 3 (30.00) | 3.03 | – | References |
| 1/2 | 4 (21.05) | 8.56 | 12 (34.29) | 15.09 | 0.827 | 1.5 (0.318–8.165) |
11 (25.00) | 18.52 | 5 (50.00) | 4.95 | 0.219 | 3.636 (0.568–26.85) |
| 1/3 | 0 (0.00) | 0 (0.00) | – | – | 0 (0.00) | 0 (0.00) | – | – | ||||
| 2/2 | 5 (26.32) | 2.72 | 5 (14.29) | 3.46 | 0.579 | 0.5 (0.089–2.852) |
8 (18.18) | 4.24 | 2 (20.00) | 2.03 | 0.824 | 2 (0.140–20.59) |
| 2/3 | 1 (5.26) | 0 (0.00) | 0.714 | 0 (0.000–21.67) |
1 (2.27) | 0 (0.00) | 1.000 | 0 (0.000–325) |
||||
| H-W | 0.078 | 0.481 | 0.029 | 0.999 | ||||||||
| Allele | ||||||||||||
| 1 | 22 (57.89%) | 48 (61.53%) | – | References | 59 (67.04%) | 11 (55%) | – | References | ||||
| 2 | 15 (39.47%) | 22 (38.46%) | 0.464 | 0.672 (0.272–1.683) |
28 (31.81%) | 9 (45%) | 0.368 | 0.383 (0.039–1.952) |
||||
| 3 | 1 (2.63%) | 0 | 0.648 | 0.000 (0.000–18.69) |
1 (1.13%) | 0 | 1.000 | 0.000 (0.000–212.7) |
||||
| IL-6−174G>C
(rs1800795) | ||||||||||||
| Genotypes | ||||||||||||
| GG | 6 (31.58) | 7.58 | 5 (14.29) | 9.26 | – | References | 9 (20.45) | 13.09 | 2 (20.00) | 3.60 | – | References |
| GC | 12 (63.16) | 8.84 | 26 (74.29) | 17.49 | 0.300 |
2.6
(0.529–12.93) |
30 (68.19) | 21.82 | 8 (80.00) | 4.80 | 1.000 |
1.2
(0.186–13.55) |
| CC | 1 (5.26) | 2.58 | 4 (11.43) | 8.26 | 0.462 |
4.8
(0.294–275) |
5 (11.36) | 9.09 | 0 (0.00) | 1.60 | 0.917 |
0
(0.000–12.15) |
| H-W | 0.298 | 0.016 | 0.045 | 0.108 | ||||||||
| Allele | ||||||||||||
| G | 24 (63.15%) | 36 (51.42%) | – | References | 48 (54.54%) | 12 (60%) | – | References | ||||
| C | 14 (36.84%) | 34 (48.57%) | 0.333 |
1.619
(0.672–3.969) |
40 (45.45%) | 8 (40%) | 0.808 |
0.764
(0.229–2.401) |
||||
| IL-6−596G>A
(rs1800797) | ||||||||||||
| Genotypes | ||||||||||||
| GG | 6 (31.58) | 7.58 | 5 (14.29) | 9.78 | – | References | 9 (20.45) | 13.64 | 2 (20.00) | 3.60 | – | References |
| GA | 12 (63.16) | 8.84 | 27 (77.14) | 17.44 | 0.274 |
2.7
(0.551–13.39) |
31 (70.45) | 21.72 | 8 (80.00) | 4.80 | 1.000 |
1.161
(0.180–13.11) |
| AA | 1 (5.26) | 2.58 | 3 (8.57) | 7.78 | 0.677 |
3.6
(0.191–219.9) |
4 (9.10) | 8.64 | 0 (0.00) | 1.60 | 1.000 |
0
(0.000–15.59) |
| H-W | 0.298 | 0.005 | 0.018 | 0.108 | ||||||||
| Allele | ||||||||||||
| G | 24 (63.15%) | 37 (52.85%) | – | References | 49 (55.68%) | 12 (60%) | – | References | ||||
| A | 14 (36.84%) | 33 (47.14%) | 0.408 |
1.529
(0.634–3.750) |
39 (44.31%) | 8 (40%) | 0.838 |
0.779
(0.234–2.448) |
||||
| TNF-α −308G>A(rs1800629) | ||||||||||||
| Genotypes | ||||||||||||
| GG | 16 (84.21) | 16.12 | 28 (80.00) | 28.35 | – | References | 36 (81.82) | 36.36 | 8 (80.00) | 8.10 | – | References |
| GA | 3 (15.79) | 2.76 | 7 (20.00) | 6.30 | 1.000 |
1.333
(0.256–9.06) |
8 (18.18) | 7.27 | 2 (20.00) | 1.80 | 1.000 |
1.125
(0.098–7.372) |
| AA | 0 (0.00) | 0.12 | 0 (0.00) | 0.35 | – | – | 0 (0.00) | 0.36 | 0 (0.00) | 0.10 | – | – |
| H-W | 0.933 | 0.806 | 0.803 | 0.940 | ||||||||
| Allele | ||||||||||||
| G | 35 (92.1%) | 63 (90%) | – | References | 80 (90.9%) | 18 (90%) | – | References | ||||
| A | 3 (2.63%) | 7 (10%) | 1.000 |
1.296
(0.273–8.236) |
8 (9.1%) | 2 (10%) | 1.000 |
1.25
(0.118–7.120) |
||||
N observed, Exp expected (genotype frequencies calculated from allele frequencies with the Hardy–Weinberg (H-W) equation)