Table 5.
Genotype distribution of the polymorphisms in infected and non-infected infants with IVH grades 1–4 or with IVH grades 3–4
| Gene symbol | Group with IVH 1–4 infected (N = 33; %) |
Exp | Group with IVH 1–4 non-infected (N = 14; %) |
Exp | p value | OR | Group with IVH 3–4 infected (N = 9; %) |
Exp | Group with IVH 3–4 non-infected (N = 2; %) |
Exp | p value | OR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IL-1β +3953C>T (rs1143634) | ||||||||||||
| Genotypes | ||||||||||||
| CC | 22 (66.67) | 21.28 | 8 (66.67) | 7.52 | – | References | 7 (77.78) | 7.11 | 2 (100.0) | 2 | – | References |
| CT | 9 (27.27) | 10.44 | 3 (25.00) | 3.96 | 1.000 | 1.091 (0.196–7.820) | 2 (22.22) | 1.78 | 0 (0.00) | 0 | – | – |
| TT | 2 (6.06) | 1.28 | 1 (8.33) | 0.52 | 1.000 | 0.727 (0.034–48.21) | 0 (0.00) | 0.11 | 0 (0.00) | 0 | – | – |
| H-W | 0.731 | 0.703 | H–W | 0.932 | – | |||||||
| Allele | ||||||||||||
| C | 53 (80.30) | 19 (79.17) | – | References | 16 (88.89) | 6 (75.00) | – | References | ||||
| T | 13 (19.70) | 5 (20.83) | 1.000 | 0.932 (0.265–3.797) | 2 (11.11) | 2 (25.00) | 0.717 | 0.375 (0.023–6.531) | ||||
| Genotypes | ||||||||||||
| 1/1 | 15 (45.45) | 12.73 | 7 (58.33) | 7.36 | – | References | 3 (33.33) | 2.78 | 1 (50.00) | 1.13 | – | References |
| IL -1RN 86 bp VNTR
(rs2234663) | ||||||||||||
| 1/2 | 11 (33.33) | 15.53 | 4 (33.33) | 3.27 | 1.000 | 1.283 (0.246–7.497) | 4 (44.44) | 4.44 | 1 (50.00) | 0.75 | 1.000 | 1.333 (0.013–130.5) |
| 1/3 | 0 (0.00) | 1 (8.33) | 0.696 | 0.000 (0.000–20.80) | 0 (0.00) | 0 (0.00) | – | – | ||||
| 2/2 | 7 (21.21) | 4.73 | 0 (0.00) | 0.36 | – | – | 2 (22.22) | 1.78 | 0 (0.00) | 0.13 | – | – |
| IL-1RN (rs2234663) 2/3 |
0 (0.00) | 0 (0.00) | – | – | 0 (0.00) | 0 (0.00) | – | – | ||||
| H-W | 0.246 | 0.762 | 0.956 | 0.895 | ||||||||
| Allele | ||||||||||||
| 1 | 41 (61.19) | 19 (82.61) | – | References | 10 (55.56) | 3 (75.00) | – | References | ||||
| 2 | 25 (38.81) | 4 (17.39) | 0.115 | 2.896 (0.819–12.92) | 8 (44.44) | 1 (25.00) | 0.899 | 2.4 (0.150–141.5) | ||||
| 3 | 0 (0.00) | 0 (0.00) | – | – | 0 (0.00) | 0 (0.00) | – | – | ||||
| IL-6−174 G>C
(rs1800795) | ||||||||||||
| Genotypes | ||||||||||||
| GG | 5 (15.15) | 7.28 | 3 (25.00) | 3.52 | – | References | 1 (11.11) | 2.78 | 1 (50.00) | 1.13 | – | References |
| GC | 21 (63.64) | 16.44 | 7 (58.33) | 5.96 | 0.777 | 1.800 (0.218–12.22) | 8 (88.89) | 4.44 | 1 (50.00) | 0.75 | 0.691 | 8 (0.051–704) |
| CC | 7 (21.21) | 9.28 | 2 (16.67) | 2.52 | 0.873 | 2.1 (0.162–32.92) | 0 (0.00) | 1.78 | 0 (0.00) | 0.13 | – | – |
| H-W | 0.281 | 0.832 | H–W | 0.056 | 0.895 | |||||||
| Allele | ||||||||||||
| G | 31 (46.97) | 13 (54.17) | – | References | 10 (55.56) | 3 (75.00) | – | References | ||||
| C | 35 (53.03) | 11 (45.83) | 0.715 | 1.334 (0.472–3.810) | 8 (44.44) | 1 (25.00) | 0.899 | 2.4 (0.150–141.5) | ||||
| IL-6−596 G>A
(rs1800797) | ||||||||||||
| Genotypes | ||||||||||||
| GG | 5 (15.15) | 7.28 | 3 (25.00) | 4.08 | – | References | 1 (11.11) | 2.78 | 1 (50.00) | 1.13 | – | References |
| GA | 21 (63.64) | 16.44 | 8 (66.67) | 5.83 | 0.888 | 1.575 (0.196–10.42) | 8 (88.89) | 4.44 | 1 (50.00) | 0.75 | 0.691 | 8 (0.051–704) |
| AA | 7 (21.21) | 9.28 | 1 (8.33) | 2.08 | 0.569 | 4.2 (0.227–251.3) | 0 (0.00) | 1.78 | 0 (0.00) | 0.13 | – | – |
| H-W | 0.281 | 0.437 | 0.056 | 0.895 | ||||||||
| Allele | ||||||||||||
| G | 31 (46.97) | 14 (58.33) | – | References | 10 (55.56) | 3 (75.00) | – | References | ||||
| A | 35 (53.03) | 10 (41.67) | 0.475 | 1.581 (0.557–4.583) | 8 (44.44) | 1 (25.00) | 0.899 | 2.4 (0.150–141.5) | ||||
| TNF-α−308G>A
(rs1800629) | ||||||||||||
| Genotypes | ||||||||||||
| GG | 26 (78.79) | 26.37 | 9 (75.00) | 9.19 | – | References | 7 (77.78) | 7.11 | 1 (50.00) | 1.13 | – | References |
| GA | 7 (21.21) | 6.26 | 3 (25.00) | 2.63 | 1.000 | 0.808 (0.142–5.898) | 2 (22.22) | 1.78 | 1 (50.00) | 0.75 | 0.982 | 0.286 (0.003–33.55) |
| AA | 0 (0.00) | 0.37 | 0 (0.00) | 0.19 | – | – | 0 (0.00) | 0.11 | 0 (0.00) | 0.13 | – | – |
| H-W | 0.793 | 0.885 | 0.932 | 0.895 | ||||||||
| Allele | ||||||||||||
| G | 59 (89.39) | 21 (87.50) | – | References | 16 (88.89) | 3 (75.00) | – | References | ||||
| A | 7 (10.61) | 3 (12.50) | 1.000 | 0.831 (0.169–5.441) | 2 (11.11) | 1 (25.00) | 0.940 | 0.375 (0.015–29.43) | ||||
N observed, Exp expected (genotype frequencies calculated from allele frequencies with the Hardy–Weinberg (H-W) equation)