Table 1.
Associations of FTO rs8050136 with changes in anthropometric and metabolic parameters a
|
FTO rs8050136 genotype |
Interaction p (intervention x FTO genotype) | ||||
|---|---|---|---|---|---|
| Before lifestyle intervention |
After 9-month lifestyle intervention |
||||
| CC | XA | CC | XA | ||
| N (f/m) | 89 (51/38) | 203 (127/76) | |||
| Age, years | 45 ± 1 | 46 ±1 | |||
| Weight, kg | 86.4 ± 1.7 | 88.0 ± 1.4 | 83.7 ± 1.6 | 85.6 ± 1.4 | 0.4 |
| BMI, kg/m2 | 29.4 ± 0.5 | 29.9 ± 0.4 | 28.5 ± 0.5 | 29.1 ± 0.4 | 0.4 |
| Body fat content, % | 32.4 ± 0.9 | 32.8 ± 0.6 | 30.7 ± 1 | 31.8 ± 0.6 | 0.1 |
| Fasting blood glucose, mmol/l | 5.2 ± 0.1 | 5.5 ± 0 | 5.2 ± 0.1 | 5.2 ± 0 | 0.9 |
| 2-hour blood glucose, mmol/l | 6.7 ± 0.2 | 7.0 ± 0.1 | 6.6 ± 0.2 | 6.7 ± 0.1 | 1.0 |
| HPA score | 8.1 ± 0.1 | 8.1 ± 0.1 | 8.6 ± 0.1 | 8.6 ± 0.1 | 0.7 |
| VO2max, ml/min/kg | 24.6 ± 0.7 | 23.7 ± 0.4 | 25.3 ± 0.7 | 25.0 ± 0.5 | 0.3 |
| IAT, W* | 69.9 ± 4.7 | 68.8 ± 3.9 | 88.0 ± 5.4 | 84.4 ± 3.9 | 0.9 |
a
Data are given as mean ± SE. p-values from a multivariate linear regression model adjusting for gender, age and baseline measurements of the respective trait using a dominant inheritance model.
*
Data available from 192 subjects (CC = 60, XA = 132)