Table 3.

Changes in blood pressure and heart rate (mean ± SD) after 24 weeks for the ITT (LOCF) population, n = 237

	Change after 24 weeks (n = 237)
	placebo	16 mg cathine	32 mg cathine	53.3 mg cathine
Systolic blood pressure, mm Hg	−1.4 ± 12.6	−5.0 ± 13.8	−0.8 ± 12.3	−4.3 ± 11.4
(p value)	(0.0892)	(0.0057)	(0.0281)	(0.0012)
Diastolic blood pressure, mm Hg	0.2 ± 7.4	−2.0 ± 7.9	0.2 ± 8.3	−1.5 ± 7.6
(p value)	(0.0830)	(0.0046)	(0.4409)	(0.0933)
Heart rate, bpm	−1.4 ± 10.3	1.2 ± 8.7	5.8 ± 11.4	6.2 ± 10.3
(p value)	(0.0002)	(0.1719)	(0.8820)	(0.7797)