Table 1.
Pre- and post-surgical median levels of BMI, HOMA-IR and diabetes and inflammatory variables of the three groups
| Group | T2DM+/+ |
T2DM+/− |
T2DM−/− |
p value | |||
|---|---|---|---|---|---|---|---|
| n | median (95% CI levels) | n | median (95% CI levels) | n | median (95% CI levels) | ||
| Pre-surgically | |||||||
| BMI, kg/m2 | 10 | 42.3 (38.8–45.8) | 19 | 42.9 (40.8–45.8) | 19 | 42.3 (37.3–46.2) | 0.645 |
| HbA1C, mmol/mol | 9 | 56 (49–86) a)**** c)* | 19 | 45 (41–50) b)**** | 19 | 37 (35–40) | <0.0001 |
| Glucose, mmol/l | 9 | 8.6 (7.2–19.0) a)****c)** | 17 | 6.3 (5.6–7.4) b)* | 19 | 5.6 (5.1–6.0) | 0.0002 |
| C-peptide, pmol/l | 10 | 843 (655–1,480) a)ns c)ns | 19 | 1,258 (947–1,635) b) | 19 | 808 (682–1,291) | 0.025 |
| Insulin, pmol/l | 4 | 117 (70–163) | 18 | 145 (119–198) | 19 | 105 (64–165) | nd |
| HOMA-IR | 4 | 6.75 (3.70–15.81) | 16 | 6.28 (4.15–8.81) | 19 | 3.76 (2.27–6.32) | nd |
| S100A8/A9, μg/l | 10 | 1,248 (701–1,972) | 19 | 979 (649–1,195) | 18 | 853 (630–1,204) | 0.278 |
| IL-6, ng/l | 9 | 2.3 (1.5–3.9) | 17 | 2.4 (2.0–3.4) | 18 | 2.6 (2.1–3.4) | 0.707 |
| CRP, mg/l | 9 | 3.0 (1.0–9.0) | 19 | 5.0 (1.0–8.0) | 19 | 6.0 (3.0–8.0) | 0.642 |
| Leukocyte count × 109/l | 10 | 7.0 (4.5–11.6) | 19 | 6.5 (5.8–7.2)) | 19 | 6.0 (5.3–7.7) | 0.456 |
| Post-surgically | |||||||
| BMI, kg/m2 | 10 | 31.0 (27.6–34.6) | 19 | 30.5 (29.2–33.6) | 19 | 30.1 (26.8–31.7) | 0.492 |
| HbA1C, mmol/mol | 10 | 48 (42–51) a)**** c)**** | 19 | 37 (33–38) b)* | 19 | 34 (32–36) | <0.0001 |
| Glucose, mmol/l | 10 | 7.2 (5.5–9.5) a)*** c)** | 18 | 5.2 (5.0–5.6) b)ns | 19 | 5.0 (4.9–5.3) | 0.0009 |
| C-peptide, pmol/l | 10 | 634 (473–798) | 19 | 738 (516–847) | 19 | 523 (417–645) | 0.052 |
| Insulin, pmol/l | 9 | 43 (32–44) | 19 | 53 (32–71) | 17 | 43 (31–64) | 0.317 |
| HOMA-IR | 9 | 1.70 (1.36–2.53) | 18 | 1.76 (1.09–2.68) | 17 | 1.33 (0.98–2.08) | 0.312 |
| S100A8/A9, μg/l | 10 | 607 (400–863) | 19 | 484 (400–710) | 18 | 537 (400–691) | 0.585 |
| IL-6, ng/l | 8 | 1.2 (0.8–5.0) | 17 | 1.7 (1.2–2.4) | 17 | 1.7 (1.2–2.9) | 0.525 |
| CRP, mg/l | 10 | 0.7 (0.3–3.0) a)ns c)ns | 19 | 1.0 (0.3–1.0) b)* | 19 | 2.0 (1.0–4.0) | 0.042 |
| Leukocyte count × 109/l | 10 | 6.3 (5.3–7.0) | 19 | 6.0 (5.2–6.4) | 19 | 5.6 (4.8–6.4) | 0.497 |
a)
Significance levels of differences between T2DM+/+ and T2DM−/−.
b)
Significance levels of differences between T2DM+/− and T2DM−/−.
c)
Significance levels of differences betweenT2DM+/+ and T2DM+/−.
*
p < 0.05
**
p < 0.01
***
p < 0.001
****
p < 0.0001
ns
= no significance; nd = not determined.