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(A) Genetic context of pyrE (STM3733) in Salmonella Typhimurium. (B) De novo pyrimidine synthesis and salvage pathways in bacteria. Pathways that produce UMP, the precursor of all pyrimidines, are shown. The six steps of the de novo pyrimidine biosynthesis pathway and their corresponding enzymes, genes in parentheses are shown. Double arrowheads indicate that the activity is capable of both conversions.
