Table 7. Comparison of discrimination and calibration for models fit by elastic net regularization versus traditional backwards selection.
| Comparison (dataset) | Elastic net regularization | Traditional backwards selection | ||
|---|---|---|---|---|
| CVD model | SAE model | CVD model | SAE model | |
| Internal validation (SPRINT data) | ||||
| Discrimination | 0.71 (0.71/0.71) | 0.71 (0.71/0.71) | 0.70 (0.70/0.70) | 0.71 (0.71/0.71) |
| Calibration slope | 1.06 (1.06/1.06) | 1.10 (1.10/1.10) | 1.08 (1.08/1.08) | 1.16 (1.16/1.16) |
| Calibration intercept | −0.004 (−0.004/−0.004) | −0.012 (−0.012/−0.012) | −0.006 (−0.006/−0.006) | −0.025 (−0.025/−0.025) |
| GND P value | 0.68 (0.68/0.68) | 0.12 (0.12/0.12) | 0.79 (0.79/0.79) | 0.24 (0.24/0.24) |
| External validation (ACCORD-BP data) | ||||
| Discrimination | 0.69 (0.69/0.69) | 0.71 (0.71/0.71) | 0.68 (0.68/0.68) | 0.60 (0.60/0.60) |
| Calibration slope | 0.96 (0.96/0.96) | 1.01 (1.01/1.01) | 1.04 (1.04/1.04) | 0.54 (0.54/0.54) |
| Calibration intercept | 0.006 (0.006/0.006) | −0.003 (−0.003/−0.003) | 0.002 (0.002/0.002) | 0.064 (0.064/0.064) |
| GND P value | 0.18 (0.18/0.18) | 0.07 (0.07/0.07) | 0.68 (0.68/0.68) | <0.001 (<0.001/<0.001) |
Values are given as overall (intervention arm/control arm).
CVD, cardiovascular disease; GND, Greenwood–Nam–D’Agostino test; SAE, severe adverse event.