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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Investig Dermatol Symp Proc. 2017 Oct;18(2):S57–S63. doi: 10.1016/j.jisp.2016.11.001

Table 3.

Mean and SEM1 of the percentage of unstimulated and LPS-stimulated CD11c+ mDCs and CD14+ monocytes from DM patients and control subjects expressing TNF-α given treatment with HCQ, QC, and sham CD11c+ mDCs

CD11c+mDCs
Treatment Mean SEM P-Value2 Treatment Mean SEM P-Value2
Sham (reference group) 5.07 2.43 — LPS (reference group) 43.78 4.40 —
HCQ 2.92 2.43 0.4528 LPS + HCQ 39.27 4.40 0.2968
QC 1.95 2.43 0.2791 LPS + QC 10.69 4.40 <0.00013
CD14+monocytes
Treatment Mean SEM P-Value1 Treatment Mean SEM P-Value1
Sham (reference group) 5.37 2.74 — LPS (reference group) 79.08 7.39 —
HCQ 2.59 2.74 0.2826 LPS + HCQ 77.87 7.39 0.7262
QC 1.31 2.74 0.1231 LPS + QC 50.08 7.39 <0.00013

Abbreviations: DM, dermatomyositis; HCQ, hydroxychloroquine; LPS, lipopolysaccharide; mDC, myeloid dendritic cell; QC, quinacrine; SEM, standard error of the mean; TNF-α, tumor necrosis factor-α.

1

The units are pg/ml.

2

Comparison with the reference group.

3

P < 0.0001 for LPS + QC versus LPS.