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Protein surface representation of wild-type CTX-M-14 (gray), S70G/P167S with bound ceftazidime (green), E166A/P167S with acylated ceftazidime (orange) and E166A with acylated ceftazidime (blue). The positions of the Ser70 and Asn170 residues are highlighted in yellow. Ceftazidime is shown as green sticks and acylated ceftazidime as orange sticks for E166A/P167S and blue sticks for E166A. Oxygen and nitrogen atoms are colored red and blue respectively.
