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. Author manuscript; available in PMC: 2018 Oct 12.
Published in final edited form as: J Med Chem. 2017 Oct 4;60(19):8103–8114. doi: 10.1021/acs.jmedchem.7b00856

Figure 1.

Figure 1

A) Sequence alignment of human ASP and AGRP. The hypothesized Arg-Phe-Phe pharmacophore region is highlighted in red. The disulfide pairing is also indicated.

B) Sequence alignment of the postulated active loop of human and mouse ASP and AGRP. The conserved Arg-Phe-Phe is highlighted in red.

C) NMR solution structures of human AGRP(87-132) (PDB = 1HYK)50 and human ASP(80-132: Q115Y, S124Y) (PDB = 1Y7K).29 The β-hairpin loops are colored red and highlighted in the red box. The Arg-Phe-Phe tripeptide side-chains are drawn to illustrate their similar positions within the structures.