Table 1.

Substrates of Neprilysin^*

Vasoactive Peptides	Mitogenesis and Angiogenesis
Adrenomedullin	Bombesin-like peptides
Angiotensin I	Fibroblast growth
Angiotensin II
Natriurietic peptides (ANP, BNP, CNP, urodilatin)	Hypothalamic-Pituitary Axis
Bradykinin	Adrenocorticotrophic hormone
Kallidin	Gonadotropin-releasing hormone
Endothelin	α-melanocyte stimulating hormone
Neurokinin A	Oxytocin
Neuropeptide Y
Substance P	Digestion and Metabolism
	Cholecystokinin
Peptides in Neurologic Processes	Gastrin-releasing peptide
Amyloid β	Glucagon
Galanin	Glucagon-like peptides
Neurotensin	Insulin-B chain
Peptide YY
Pain and Inflammation
Calcitonin gene-related peptide
Dynrophin
β endorphin
Enkephalins
Neurokinin A
Vasoactive intestinal peptide

^*Adapted from Campbell, Nature Reviews Cardiology