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. 2017 Sep 15;7:45–56. doi: 10.1016/j.omto.2017.09.004

Figure 3.

Figure 3

Peripheral Priming Reduces VSVΔ51 Infection in the Healthy Brain

(A) VSV antigen was detected by immunohistochemistry in the brains of BALB/c mice primed for 24 hr and treated IC for 24, 72, or 96 hr. Solid arrows highlight the choroid plexus; dashed arrows highlight the lateral ventricles. Scale bar, 3 mm. (B) Co-localization immunofluorescent analysis of VSV antigen (green) with different brain cell populations at 24 hr post-IC treatment. Sections were labeled with Texas Red secondary antibodies, including neurons (NeuN+), microglia/endothelia (RCA-1+), and astrocytes/ependymal cells (GFAP+). Hoescht (blue) was applied for nuclear staining. Images taken at 20x magnification.