TABLE 2.

Baseline and Post-CCl₄ Treatment Apparent Diffusion Coefficients (ADC) for Each CD1 Mouse

	BASELINE ADC [×(10−3mm2/s]		POST-CCl4 ADC [×(10−3 mm2/s]			Pathology
ID	[1H] water	[13C,15N] urea	Treatment Duration [weeks]	[1H] water	[13C,15N] urea	Fibrosis pattern	Modified Brunt staging	Centrizonal inflammation grade	Centrizonal pigmented macrophages per HPF	Councilman bodies per 10 HPF
1	0.66	0.54	7	0.78	0.85	Early centrizonal	1–2	0–1	4	1
	R2 = 0.93	R2 = 0.89		R2 = 0.97	R2 = 0.98
2	0.76	0.81	7	0.96	0.80	Centrizonal pericellular	2	0–1	3	3
	R2 = 0.80	R2=1		R2 = 0.89	R2 = 0.95
3	0.91	1.2	7	1.10	0.79	Centrizonal with early septal	2–3	1–2	4	4
	R2 = 0.97	R2 = 0.96		R2 = 0.86	R2 = 0.93
4	0.81	0.53	7	0.64	0.96	Centrizonal pericellular	2	0–1	12	0
	R2 = 0.97	R2 = 0.98		R2 = 0.65	R2 = 0.81
5	0.66	0.75	11	0.91	0.47	Centrizonal pericellular	2	0–1	6	2
	R2 = 0.99	R2 = 0.99		R2 = 0.91	R2 = 0.99
6	0.61	0.60	11	0.57	0.78	Centrizonal with early septal	2–3	1	8	3
	R2 = 0.85	R2 = 0.96		R2 = 0.84	R2 = 0.83
7	0.88	0.91	11	1.10	0.60	Centrizonal with early septal	2–3	1	8	2
	R2 = 0.99	R2 = 0.97		R2 = 0.93	R2 = 0.64
8	0.70	0.85	11	0.76	0.77	Centrizonal pericellular	2	1–2	2–3	4
	R2=l	R2 = 0.98		R2 = 0.73	R2 = 0.75
Mean	0.75 ±0.11	0.75 ± 0.22		0.84 ± 0.22	0.75 ±0.15

Values shown are the ADC measured in units of 10⁻³ mm²/s, along with R² , which is the coefficient of variation for the exponential fit. Mice 1–4 were treated with CCl₄ for 7 weeks and mice 5–8 were treated with CCl₄ for 11 weeks. The last row displays the mean ± standard deviation of the eight measurements. Centrizonal inflammation grade: 1 < 33%, 2 < 66% and 3 < 100%. All inflammation demonstrated a lymphocyte-predominant pattern.