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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Circulation. 2017 Aug 4;136(16):1477–1491. doi: 10.1161/CIRCULATIONAHA.117.028585

Figure 3. MYBPHL expression is enriched in human and mouse atria and is distinct from MYBPH.

Figure 3

A. Schematic of human chromosomes 1 and 11 show locations of the three genes MYBPHL, MYBPH, and MYBPC3. B. Human RNA-Seq data from the GTEx database of normalized MYBPHL and MYBPH reads in ventricle, atria, and skeletal muscle shows enriched MYBPHL expression in atrial tissue, and enriched MYBPH expression in skeletal muscle (MYBPHL n= 218 LV, 194 atria, 229 skel; MYBPH n= 218 LV, 194 atria, 232 skel). C. RNA-Seq data from mouse tissue shows enrichment of MYBPHL expression in ventricle and enrichment of MYBPH in skeletal muscle (n=6). D. qPCR analysis of wild-type mouse ventricle, atria, and skeletal muscle confirms the cardiac and atrial enrichment of MYBPHL and the enrichment of MYBPH in skeletal muscle (n=4). *= p<0.05 two-way ANOVA with a Bonferroni multiple comparison test (B,C) or one-way ANOVA with a Tukey’s post-hoc test (D).