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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Colloids Surf B Biointerfaces. 2017 Jul 15;158:356–362. doi: 10.1016/j.colsurfb.2017.07.014

Figure 6.

Figure 6

Effect of pegylation and kupffer cell depletion on liposome accumulation in the mononuclear phagocyte system of mice. (a) Immunofluorescence images of liver sections. Kupffer cell depletion was achieved with intravenous injections of clodronate liposomes (clodrolip; 50 mg/kg clodronate). Kupffer cells, purple (F4/80 antibody); DAPI, blue. Scale bar, 100 μm. (b,c) The plasma/liver (b) and plasma/spleen (c) liposome accumulation ratios (g tissue) 24 h after intravenous injection. Data is presented as mean ± s.d. (n = 5). The student’s t-test was used to calculate statistical significance. **, P < 0.01; ***, P < 0.001.