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Simulation Results for Acyclovir Following Escalating Oral Doses of Valacyclovir in Wildtype and Pept1 Knockout Mice
| Genotype | Dose (nmol/g) |
Cmax (μM) |
AUC0–180 (min·μmol/L) |
r2 | ||
|---|---|---|---|---|---|---|
| Observed | Predicted | Observed | Predicted | |||
| Wildtype | 10 | 3.8 | 3.9 | 278 | 279 | 0.898 |
| 25 | 9.6 | 9.7 | 663 | 691 | 0.969 | |
| 50 | 20.9 | 19.0 | 1675 | 1364 | 0.902 | |
| 100 | 40.6 | 35.9 | 2923 | 2636 | 0.875 | |
| Pept1 Knockout | 10 | 0.9 | 1.0 | 128 | 131 | 0.897 |
| 25 | 1.7 | 1.8 | 235 | 238 | 0.877 | |
| 50 | 5.0 | 5.2 | 743 | 687 | 0.814 | |
| 100 | 8.8 | 8.8 | 1233 | 1176 | 0.885 | |
