Table 1.
Description of the Study Population by Type of Persistent Autoantibody. Values are Reported as n (% of Non-Missing Observations) for Categorical Variables and Median (Interquartile Range) for Continuous Variables.
| Variable | Total | Type of persistent autoantibody | ||
|---|---|---|---|---|
|
| ||||
| IAA | GADA | IA2A | ||
| Total number of children | 613 | 442 | 466 | 288 |
| Age at respective seroconversion (years) | 2.2 (1.2, 3.8) | 2.0 (1.1, 3.5) | 2.7 (1.6, 4.2) | 2.8 (1.9, 4.5) |
| Girls | 268 (44%) | 200 (45%) | 212 (45%) | 112 (39%) |
| Country | ||||
| US | 206 (34%) | 136 (31%) | 166 (36%) | 94 (33%) |
| Finland | 153 (25%) | 125 (28%) | 109 (23%) | 85 (30%) |
| Germany | 47 (8%) | 40 (9%) | 32 (7%) | 22 (8%) |
| Sweden | 207 (34%) | 141 (32%) | 159 (34%) | 87 (30%) |
| Child having a first degree relative with T1D | 128 (21%) | 105 (24%) | 97 (21%) | 71 (25%) |
| HLA-DR genotype | ||||
| DR3/4 | 311 (51%) | 241 (55%) | 251 (54%) | 148 (51%) |
| DR4/4 | 106 (17%) | 74 (17%) | 81 (17%) | 64 (22%) |
| DR4/8 | 92 (15%) | 71 (16%) | 51 (11%) | 46 (16%) |
| DR3/3 | 76 (12%) | 30 (7%) | 64 (14%) | 16 (6%) |
| other | 28 (5%) | 26 (6%) | 19 (4%) | 14 (5%) |
| Additionally autoantibody positive for | ||||
| IAA | 302 (65%) | 252 (88%) | ||
| GADA | 302 (68%) | 237 (83%) | ||
| IA2A | 252 (57%) | 237 (51%) | ||
| Autoantibody present at first seroconversion | 353 (80%) | 344 (74%) | 40 (14%) | |
| Number of children who developed T1D | 175 (29%) | 162 (37%) | 134 (29%) | 127 (44%) |