Figure 7.

Effects of SIRT2 inhibition on tumor metastasis.

(A) Systemic delivery of SirReal2 suppresses HCC cell liver metastasis in nude mice. Levers were photographed after all animals were sacrificed. Xenograft samples were stained with hematoxylin and eosin. Scale bars, 200 μm. (B) The number of liver metastases. (C) The body weights of tumor-burdened mice. (D-E) The immunohistochemistry staining of liver metastasis in nude mice. Xenograft samples were stained as indicated. Scale bars, 100 μm. Data represent the mean ± SEM, n = 5. *P < .05, **P < .01.