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. 2017 Oct 17;7:13334. doi: 10.1038/s41598-017-13477-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased MSC Proliferation Rates and Decreased Time to Passage 1. (A) The average number of days to reach similar levels of surface area coverage and for passaging from p0 to p1 and the average percent (%) increase in cell number/cm² across the different culture conditions compared to classic normoxia conditions. n = 5–8; *p = 0.002 vs. normoxia, ^†p < 0.0001 vs. normoxia. (B) Proliferation assay for each culture condition. n = 5–8; *p < 0.001 normoxia vs. normoxia+bFGF at d14 and d21; ^†p < 0.001 vs. normoxia and normoxia+bFGF; ^‡p < 0.001 vs. normoxia and normoxia+bFGF, ^‡p < 0.005 vs. hypoxia; data presented as mean ± S.E.M.