Table 3.
Molecular changes in the AM - Comparison of molecular events between the AG and GC groups.
| No. of biopsy specimens | AG group | GC group | P | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|---|
| n = 56 | (%) | n = 26 | (%) | OR (95% CI) | P | Gender-adjusted OR (95% CI) | P | ||
| MSI | 4 | (7.1) | 2 | (9.1) | 1 | ||||
| CIMP | 2 | (3.6) | 3 | (11.5) | 0.32 | ||||
| CDH1 | 8 | (14.3) | 17 | (65.4) | <0.0001 | 8.50 (2.64–25.33) | 0.0003 | 7.71 (2.34–25.42) | 0.0008 |
| CDKN2A | 1 | (1.8) | 0 | (0) | 1 | ||||
| MLH1 | 0 | (0) | 0 | (0) | 1 | ||||
| MGMT | 1 | (1.8) | 0 | (0) | 1 | ||||
| MINT1 | 5 | (8.9) | 8 | (30.8) | 0.02 | 1.26 (0.24–6.55) | 0.78 | 1.32 (0.26–6.78) | 0.74 |
| MINT31 | 2 | (3.6) | 7 | (26.9) | 0.004 | 4.08 (0.55–30.32) | 0.11 | 4.30 (0.54–34.36) | 0.17 |
| RUNX3 | 0 | (0) | 0 | (0) | 1 | ||||
AM, atrophic mucosa; AG, atrophic gastritis; GC, gastric cancer; OR, odds ratio; CI, confidence interval; MSI, microsatellite instability; CIMP, CpG island methylator phenotype