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. 2017 Oct 17;7:13357. doi: 10.1038/s41598-017-13488-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypothetical model of regulation of Cx43 forward trafficking and GJ formation by PR isoforms in human myocyte during pregnancy and labour. Model shows that during pregnancy P4-liganded PRB inhibits forward trafficking of Cx43/GJ formation by inhibiting Cx43-20 K expression/translation which results in accumulation of Cx43 in the ER and no cell-cell connectivity between myocytes. During labour P4-liganded PRA promotes Cx43 forward trafficking/GJ formation by inducing Cx43-20 K expression (which facilitates ER to Golgi transport of Cx43) and ensuring cell-cell connectivity to synchronize myometrial contractions during labour.