Table 2.
Eleven potential ICC marker genes were obviously up-regulated in nras 61K transgenic zebrafish.
| EntrezGen IDs from Zebrafish | Gene Symbol | Gene Name | Expression Changes in Zebrafish ICC (log2 ratio) | Expression p-value | qRT-PCR (log2 ratio) | RT p-value |
|---|---|---|---|---|---|---|
| ENSDARG00000070480 | agr2 # | Anterior gradient 2 | 3.89 | 3.28E-20 | 4.2 | <0.0001 |
| ENSDARG00000087841 | ece2 * | Endothelin converting enzyme 2 | 3.36 | 1.21E-13 | 4.23 | <0.0001 |
| ENSDARG00000052115 | ehf # | Ets homologous factor | 2.16 | 1.30E-08 | 1.8 | <0.0001 |
| ENSDARG00000040534 | epcam # | Epithelial cell adhesion molecule | 2.51 | 3.63E-58 | 2.08 | 0.0001 |
| ENSDARG00000011600 | epha4 * | Eph receptor A4 | 3.62 | 2.44E-25 | 5.07 | <0.0001 |
| ENSDARG00000077296 | eps8l3 # | EPS8-like 3 | 2.18 | 1.40E-25 | 3.4 | <0.0001 |
| ENSDARG00000002494 | itgb6 # | Integrin, beta 6 | 2.78 | 1.41E-08 | 2.47 | <0.0001 |
| ENSDARG00000017127 | pdzk1ip1 # | PDZK1 interacting protein 1 | 1.75 | 9.51E-34 | 1.12 | <0.0001 |
| ENSDARG00000102381 | slc44a4 # | Solute carrier family 44, member 4 | 4.75 | 8.07E-08 | 3.26 | <0.0001 |
| ENSDARG00000029866 | slc6a # | Solute carrier family 6 (amino acid transporter), member 14 | 3.65 | 4.81E-42 | 2.85 | <0.0001 |
| ENSDARG00000069476 | spint2 # | Serine peptidase inhibitor, Kunitz type, 2 | 1.98 | 4.05E-91 | 1.18 | 0.0004 |
*Those genes are highly mutated in human ICC.
#Those genes are highly expressed in human ICC.