Table 3.

Regression analyses of the presence of DELC in cognitively impaired patients based on WMH category and Aβ-positivity.

	N	Univariate analyses		Multivariate analyses†
		Presence of DELC		Presence of DELC
		OR (95% CI)	P-value	OR (95% CI)	P-value
WMH−/Aβ− group	57	Reference		Reference
WMH−/Aβ+ group	137	2.39 (1.24–4.61)	0.010	2.94 (1.39–6.20)	0.005
WMH+/Aβ− group	150	4.31 (2.23–8.32)	<0.001	3.29 (1.59–6.82)	0.001
WMH+/Aβ+ group	127	7.29 (3.63–14.63)	<0.001	7.32 (3.35–16.01)	<0.001

^†Multivariate logistic regression analyses were performed after adjusting for age, sex, hypertension, diabetes mellitus, hyperlipidemia, history of stroke and ischemic heart disease, and APOE ε4 status.

Abbreviations: WMH = white matter hyperintensities; Aβ = amyloid-beta; DELC = diagonal earlobe crease; OR = odds ratio; CI = confidence interval; N = number; APOE = apolipoprotein E; WMH−/Aβ− = patients with minimal WMH and Aβ-negative; WMH−/Aβ+ = patients with minimal WMH and Aβ-positive; WMH+/Aβ− = patients with moderate to severe WMH and Aβ-negative; WMH+/Aβ+ = patients with moderate to severe WMH and Aβ-positive.