Table 1.
Body weight and lipid levels.
| 6 weeks WD | p | 24 weeks WD | p | |||
|---|---|---|---|---|---|---|
| LDLR−/− | LDLR−/−LMP7−/− | LDLR−/− | LDLR−/−LMP7−/− | |||
| Body weight, g | 31.2 ± 1.5 | 29.4 ± 2.2 | 0.045 | 36.6 ± 4.5 | 34.6 ± 5.5 | 0.36 |
| Body weight gain, g | 6.6 ± 0.2 | 6.4 ± 0.8 | 0.732 | 12.1 ± 2.4 | 10.0 ± 3.9 | 0.323 |
| TC, mg/dl | 1318.7 ± 138.6 | 1281.2 ± 181.0 | 0.591 | 1289.5 ± 265.4 | 1398.4 ± 417.1 | 0.47 |
| HDL-C, mg/dl | 127.7 ± 23.4 | 135.6 ± 24.7 | 0.448 | 247.6 ± 74.6 | 247.1 ± 78.3 | 0.989 |
| Non-HDL-C, mg/dl | 1191.0 ± 135.6 | 1145.6 ± 168.3 | 0.494 | 1041.9 ± 232.8 | 1151.3 ± 376.4 | 0.417 |
| Triglycerides, mg/dl | 539.7 ± 165.7 | 708.2 ± 187.3 | 0.023 | 393.9 ± 155.6 | 482.4 ± 195.8 | 0.26 |
n = 11 per group, except LDLR−/−LMP7−/− 24 weeks WD n = 12; data are shown as mean ± SD. Statistical analysis using unpaired t-test or Mann-Whitney U test. WD, Western-type diet; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol.