Table 1.
Genes | Description | Total SNPs in PolyStrat | Case-abundant SNPs in PolyStrat | PolyStrat category (one-sided burden P) |
---|---|---|---|---|
LIPH a | Lysophosphatidic acid production61 | 7 | 6 (86%) | Overall (4 × 10−4) |
NRXN1 | Encodes a synapse adhesion molecule | 8 | 8 (100%) | Exon-Cons (2 × 10−4) |
13 | 10 (77%) | Exon-All (2 × 10−4) | ||
12 | 10 (83%) | Exon-Evo (3 × 10−4) | ||
HTR2A | Indirect target for SSRI medications50 | 4 | 4 (100%) | Exon-Cons (9 × 10−4) |
CTTNBP2 | Modulates postsynaptic cortactin62 | 5 | 3 (60%) | DHS-Cons (5 × 10−4) |
15 | 8 (53%) | DHS-All (9 × 10−4) | ||
REEP3 | Regulates cellular vesicle trafficking | 3 | 3 (100%) | Overall-Div (1 × 10−4) |
4 | 4 (100%) | DHS-Evo (6 × 10−4) | ||
6 | 5 (83%) | DHS-All (8 × 10−4) |
aSignificance of association possibly inflated by linkage between markers