Fig. 6.

Treating ssTBI mice with 3 i.p. cis mAb with 4 or 8 h delay eliminates cis P-tau and restores sensorimotor coordination deficits at 2 weeks after injury. Treating ssTBI mice with 3 i.p. of cis mAb even with 4 or 8 h delay a effectively eliminated cis P-tau induction b, and restored sensorimotor coordination deficits (ledge assay and string suspension assay) c, d. Urinary incontinence was not observed after 2-weeks e. Orange arrows, ssTBI; black arrows, antibody injection; green arrows, functional, or pathological assays. The data were presented as means ± SEM. The p-values were calculated using unpaired two-tailed parametric Student’s t-test. *p < 0.05, NS, not significant