Table 2.

Pathological and genetic features of the three main swine breeds bearing cutaneous malignant melanomas.

		MeLiM	Sinclair	MMS-Troll
Breed features	Origin	Hormel	Hormel	Hanford
	Coat color	Red or black
Melanoma traits	Age of onset	At birth or in the first weeks
	Clinics	Single or multiple lesions, clinical ulceration, local or distant metastasis
	Histology	SSM and NM subtypes, presence of flat benign lesions, Clark’s level I-V, histological ulceration, skin invasion to dermis or subcutaneous adipose tissue, heavily pigmented melanoma cells and presence of pigment-laden macrophages
	Regression	Spontaneous and total
	Depigmentation	Partial or total, affecting hair, skin, and eye
	Mode of inheritance	2–3 loci, or complex autosomal dominant with incomplete penetrance	One major unmapped locus + SLA “B haplotype”	For nevi: one major gene and polygenic background
				For melanoma: two to three recessive genes
				No influence of SLA
	Reference	Geffrotin et al., 2004; Hruban et al., 2004; Vincent-Naulleau et al., 2004; Du et al., 2007	Millikan et al., 1974; Hook et al., 1979; Tissot et al., 1987; Green et al., 1992; Misfeldt and Grimm, 1994; Gomez-Raya et al., 2007; Ho et al., 2010	Müller et al., 2001; Dieckhoff et al., 2007