Figure 3.
Diabetes and obesity disease-associated spatial SNPs with significant eQTL effects (FDR > 0.05) are unevenly distributed throughout human tissues. Tissues with <10% total number of spatial eQTL SNPs in type 2 diabetes and obesity include the liver (1.3, 3.9%), stomach (7.5, 9.7%), and pituitary gland (8.1, 8.2%) respectively. Other tissues: adrenal gland, atrial aorta, coronary artery, brain - anterior cingulate cortex (BA24), brain - caudate basal ganglia, brain - cortex, brain - frontal cortex (BA9), brain - hippocampus, brain - hypothalamus, brain - nucleus accumbens basal ganglia, brain - putamen basal ganglia, breast - mammary tissue, sigmoid colon, transverse colon, gastroesophageal junction, liver, ovary, pituitary, prostrate, spleen, stomach, testis, uterus, and vagina. All eQTL SNP-genes included in this analysis were expressed with an RPKM of >1.0 (GTEx version 4.1, accessed on 09/30/16).