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. 2017 Oct 13;8:735. doi: 10.3389/fphar.2017.00735

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Copyright © 2017 Abd El-Aal, Abd El-Fattah and El-Abhar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Descriptive images of H&E staining (top) displaying the neuroprotective effect of Rosuvastatin and/or CoQ10 on hippocampal CA1 area. (A,a) Sham group, (B,b) I/R, (C,c) I/R+RUS, (D,d) I/R+CoQ10, and (E,e) I/R+RUS+CoQ10. Histological examinations were achieved 5 days following 60 min ischemia. Arrows point to damaged neurons (x400). Lower panel indicates the mean number of salvaged neurons per mm in the CA1 subfield. Rosuvastatin (RUS; 10 mg/kg), CoQ10 (10 mg/kg), and their combination were administered p.o. for 7 days before ischemic insult. Values are presented as mean (n = 6) ± SEM. Statistical analysis was carried out using one-way ANOVA followed by Tukey’s post hoc multiple comparison test. As compared with (#) sham-operated, (^∗) I/R, (†) RUS, (‡) CoQ10, and (§) combination pretreated groups (P < 0.05).