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. 2017 Oct 13;8:735. doi: 10.3389/fphar.2017.00735

FIGURE 5.

FIGURE 5

Rosuvastatin and/or CoQ10 upregulate the hippocampal protein expression of p-Akt and p-FOXO3A with the decline of FOXO3A nuclear translocation and Bim. Representative Western blots and optical densities of (A) p-Akt, (B) p-FOXO3A, (C) nuclear FOXO3A, and (D) Bim in rats subjected to transient ischemia. Measurements were achieved 24 h following 60 min ischemia. Rosuvastatin (RUS; 10 mg/kg), CoQ10 (10 mg/kg), and their combination were administered p.o. for 7 days before ischemic insult. Values are presented as mean (n = 6) ± SEM. Statistical analysis was carried out using one-way ANOVA followed by Tukey’s post hoc multiple comparison test. As compared with (#) sham-operated, (∗) I/R, (†) RUS, and (‡) CoQ10, and (§) combination pretreated groups (P < 0.05).