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. 2017 Oct 13;8:735. doi: 10.3389/fphar.2017.00735

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Copyright © 2017 Abd El-Aal, Abd El-Fattah and El-Abhar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rosuvastatin and/or CoQ10 abate hippocampal cytochrome c, Bax, and caspase-3 activity with the enhancement of Bcl2 levels. Representative Western blots and optical densities of (A) Cytochrome c, (B) Bax, (C) Bcl2, and (D) caspase-3 activity in rats subjected to transient ischemia. Measurements were achieved 24 h following 60 min ischemia. Rosuvastatin (RUS; 10 mg/kg), CoQ10 (10 mg/kg), and their combination were administered p.o. for 7 days before ischemic insult. Values are presented as mean (n = 6) ± SEM. Statistical analysis was carried out using one-way ANOVA followed by Tukey’s post hoc multiple comparison test. As compared with (#) sham-operated, (^∗) I/R, (†) RUS, (‡) CoQ10, and (§) combination pretreated groups (P < 0.05).