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Differences in the most representative bacterial functional classes (KEGG categories level 3). (A–D) Functional pathways significantly enriched in African and European populations based on PICRUSt prediction. LEfSe results indicate a sequentially significant ranking among populations (Alpha value = 0.05 for the factorial Kruskal–Wallis test among classes). The threshold for the logarithmic LDA score was 2.0.
