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CoQ10/TPGS micelles but not TPGS alone are neuroprotective against mitochondrial targeted cytotoxic insults in mixed murine retinal cultures containing RGCs. Pre-treatment of primary mixed murine retinal cell cultures with CoQ10/TPGS micelles (20 μM CoQ10 and 57 μM TPGS) but not equivalent concentrations of TPGS only significantly (two-way ANOVA, p = 0.033 and p = 0.0002 respectively) reduced the susceptibility of these cells to [A] DMSO and [B] paraquat-induced cytotoxicity.
