Fig. 4.

CoQ10/TPGS or TPGS eye drop administration did not significantly affect IOP elevation induced by the OHT model. IOP profiles in DA rats after induction of OHT demonstrate a significant increase in IOP versus contralateral eyes [A–C] (Two-way repeated measures ANOVA with Bonferroni post-test, ***p < 0.001, **p < 0.01). Treatment of eyes with topical administration of CoQ10/TPGS [B] or TPGS only micelles [C] did not significantly alter the IOP profiles compared on OHT induction (two-way repeated measures ANOVA with Bonferroni post-test versus OHT model, p > 0.05) [D] suggesting any neuroprotective activity of treatments was a result of IOP independent effects. Results are mean ± SD.